|Posted by LushingtonTechWriter on July 25, 2013 at 12:10 AM|
My latest service project was a detailed proof and critique of three substantially revised chapters of Richard Silverman's well known text book, "The Organic Chemistry of Drug Design and Drug Action", whose third edition should be coming out fairly soon. Obviously I shouldn't share my specific comments in an open blog prior to publication, but a few general impressions:
First and foremost, the book is huge and exceptionally comprehensive. The second chapter alone (out of eight) on "Lead Discovery and Lead Modification" is longer and more detailed than many actual books. Given their time pressures, students using this text for an actual course may bemoan the amount of material to be assimilated and committed, but anyone who continues on in the drug development field should hold onto this book as an excellent resource to be perused later in conjunction with practical research. There is a wealth of detailed examples that illustrate the practical trial and error experience underlying numerous key drug discoveries of the past. The book also bravely enters the information age with a detailed catalog of relevant URLs addressing relevant software, online resources, published references, and so forth. This information may fall out of date in the years between the pending release of the third edition and some future eventual version, but those students who encounter the book in the next few years should greatly appreciate its detailed compilation of links.